Assessing a conceptual model of over-the-counter medication misuse, adverse drug events and health-related quality of life in an elderly population
| Autor: | Sujit S. Sansgiry, Shivani K. Mhatre |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Health related quality of life
Drug medicine.medical_specialty Short form 12 business.industry media_common.quotation_subject 010102 general mathematics Alternative medicine Physical health 01 natural sciences humanities 03 medical and health sciences 0302 clinical medicine Quality of life Elderly population Emergency medicine medicine Over-the-counter 030212 general & internal medicine 0101 mathematics Psychiatry business media_common |
| Zdroj: | Geriatrics & Gerontology International. 16:103-110 |
| ISSN: | 1444-1586 |
| Popis: | Aim The objectives of the present study were to test Spilker's quality of life model in the elderly population consuming over-the-counter (OTC) medications. It was hypothesized that OTC medication misuse increases adverse drug events (ADEs), ADEs as a result of OTC medication misuse decrease health-related quality of life (HRQoL) and the impact of OTC medication misuse on patients' HRQoL is fully medicated by ADEs associated with OTC medications. Methods Data were used from a previously carried out cross-sectional study using survey instruments with elderly patients consuming OTC medications in Houston, Texas, USA. The presence/absence of OTC misuse was assessed by an expert panel based on patient reported information on drug use characteristics; ADE was self-reported and HRQoL was measured using the Short Form-12v2, which contains a physical component summary score (PCS) and a mental component summary score (MCS). Results Of the 154 respondents, 18.2% misused OTC medications and 22.1% reported ADE as a result of OTC medications. The mean ± SD score of PCS and MCS was 40.6 ± 6.8 and 46.4 ± 7, respectively. The hypothesized framework provided a well-fitted solution to the data (χ2 = 1.387, d.f. = 2, P = 0.49; weighted root mean square residual = 0.317). Misuse of OTC medications significantly increased ADEs associated with OTC medications (β = 0.298) and increased ADEs significantly decreased patient reported PCS (β = −0.312), but not MCS (β = −0.213). OTC medication misuse indirectly decreased PCS and MCS by mediating the effect of an increase in ADE; however, the association was not statistically significant. Conclusions Misuse of OTC medications is highly associated with ADEs. ADEs are capable of decreasing the physical health of elderly patients. Geriatr Gerontol Int 2015; ●●: ●●–●●. |
| Databáze: | OpenAIRE |
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