Decarbonylative cross coupling of phthalimides with diorganozinc reagents—Efforts toward catalysis
| Autor: | Kimberly S. DeGlopper, Sarah K. Fodor, Jeffrey B. Johnson, Thomas B. D. Endean |
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| Rok vydání: | 2016 |
| Předmět: |
Phthalimides
010405 organic chemistry Chemistry Ligand Substrate (chemistry) 010402 general chemistry 01 natural sciences 0104 chemical sciences Catalysis Inorganic Chemistry Phthalimide chemistry.chemical_compound Catalytic cycle Reagent Materials Chemistry Polar effect Organic chemistry Physical and Theoretical Chemistry |
| Zdroj: | Polyhedron. 114:393-398 |
| ISSN: | 0277-5387 |
| Popis: | The decarbonylative coupling of phthalimides with diorganozinc reagents to form o-substituted benzamides has been previously demonstrated as a viable process, but only with stoichiometric nickel(0). Investigations into a number of reaction variables, including solvent, ligand, and substrate substitution, have yielded multiple sets of conditions capable of achieving up to 10 catalyst turnovers, most successfully with the use of electron withdrawing nitrogen substituents on the phthalimide. In addition, these investigations have provided insight into the intermediates within the catalytic cycle and have revealed new approaches to the development of a general catalytic methodology. |
| Databáze: | OpenAIRE |
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