Structural Characterization of Agonist Binding to an A3 Adenosine Receptor through Biomolecular Simulations and Mutagenesis Experiments
| Autor: | Kerry Barkan, Antonios Kolocouris, Panagiotis Lagarias, Eleni Vrontaki, Graham Ladds, Dimitrios Stamatis |
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| Rok vydání: | 2019 |
| Předmět: |
Agonist
0303 health sciences medicine.drug_class Chemistry Cancer cell proliferation Mutagenesis Drug target A3 ADENOSINE RECEPTOR Adenosine A3 receptor 01 natural sciences Adenosine 0104 chemical sciences 010404 medicinal & biomolecular chemistry 03 medical and health sciences Drug Discovery medicine Biophysics Molecular Medicine 030304 developmental biology medicine.drug |
| Zdroj: | Journal of Medicinal Chemistry. 62:8831-8846 |
| ISSN: | 1520-4804 0022-2623 |
| Popis: | The adenosine A3 receptor (A3R) binds adenosine and is a drug target against cancer cell proliferation. Currently, there is no experimental structure of A3R. Here, we have generated a molecular mod... |
| Databáze: | OpenAIRE |
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