AB0191 Frequency of Antibodies Against α-Fodrin in Patients with Primary SjÖgren's Syndrome
| Autor: | Marina Claudia Khoury, Amalia Schiel, M. Rivero, D. Duartes Noe, S. Velez, J.C. Barreira, F. Zazzetti |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
education.field_of_study biology business.industry Immunology Population Hypergammaglobulinemia Autoantibody medicine.disease Gastroenterology General Biochemistry Genetics and Molecular Biology Confidence interval Serology stomatognathic diseases Titer Rheumatology Internal medicine medicine biology.protein Immunology and Allergy Clinical significance Antibody education business |
| Zdroj: | Annals of the Rheumatic Diseases. 74:955.1-955 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2015-eular.1656 |
| Popis: | Background The continuous overexpression of B lymphocytes in Primary Sjogren's syndrome (pSS) produces a variety of autoantibodies, like anti-Ro/SS-A or anti-La/SS-B, required for the diagnosis, albeit others pose an uncertain clinical significance. According to recent data, anti-α-fodrin antibodies could be used as a reliable diagnostic marker in those patients seronegative to other antibodies. Objectives Thus, the aim was to determine the frequency of anti-α-fodrin antibodies in patients withpSS and describe their clinical association. Methods Forty patients, who fulfilled the 2002 American-European criteria for pSS and 23 controls matched for age and gender, were included. Those who had received any biologic therapy were excluded. Demographic data, clinical manifestations and laboratory findings were recorded. Minor salivary gland biopsies were considered positive according to Chisholm scale. Anti-α-fodrin antibodies were determined utilizing an ELISA immunoassay (Orgentec-Germany) according to the manufacturer's instructions. Mann-Whitney test was used to compare numeric variables, and chi-square or Fisher's test for categorical. A p value of 0.05 was considered statistically significative. Confidence intervals (CI) were estimated for a value of 95%. Results Of the 40 patients with pSS, 22 (55%) tested positive for anti-α-fodrin antibodies, with a sensitivity of 100% (CI =40% - 70%) and a specificity of 56% (CI =40% - 70%). All controls resulted negative (p |
| Databáze: | OpenAIRE |
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