| Popis: |
Histological samples of organs obtained from 72 (35 male and 37 female) cynomolgus monkeys (M. fascicularis) from negative control groups in 12 toxicological studies were analyzed retrospectively. The most common processes where focal accumulations of exogenous pigment were found in 76.4% of animals in the lungs, non-atrophic chronic gastritis, which was observed in 37.4% of animals, focal chronic quiescent colitis was noted in 36.1% of cases, infiltrate in the liver were observed in 33.3% of animals, focal chronic quiescent gastritis was identified in 30.5% of animals, lymphoplasmacytic infiltrates in the kidneys were found in 26.4% of animals. Identification and accumulation of information on background pathology findings in primates from control groups are essential since these data allow differentiating spontaneous pathology from abnormalities associated with administration of a drug test, to correctly interpret the results of toxicology studies. |
