Vitamin E protects developing rat hippocampus and cerebellum against ethanol-induced oxidative stress and apoptosis
| Autor: | Alireza Shirpoor, Marine Yeghiazaryan, Siamak Salami, Mohammad Hassan Khadem-Ansari, Firouz Ghaderi-Pakdel, Syranush Minassian |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Antioxidant biology medicine.medical_treatment Vitamin E General Medicine Oxidative phosphorylation Protein oxidation medicine.disease_cause Analytical Chemistry Superoxide dismutase Lipid peroxidation chemistry.chemical_compound Endocrinology chemistry Catalase Internal medicine biology.protein medicine Oxidative stress Food Science |
| Zdroj: | Food Chemistry. 113:115-120 |
| ISSN: | 0308-8146 |
| DOI: | 10.1016/j.foodchem.2008.07.034 |
| Popis: | It has been suggested that developmental alcohol-induced brain damage is mediated through increases in oxidative stress. Current research suggests that antioxidant therapy may afford some level of protection against the toxicity of alcohol and alcoholic beverage in cellular and genomic levels. Seven day pregnant wistar rats were randomly divided into three groups: control, ethanol and vitamin E treated alcoholic groups. Apoptosis, lipid peroxidation and protein oxidation amounts, as well as, catalase and superoxide dismutase (SOD) activities were compared in male offspring hippocampus and cerebellum in the end of lactation. Offspring from ethanol-exposed animals showed significant increase in apoptosis, protein carbonyl and lipid hydroperoxide (LPO) in hippocampus and cerebellum than controls. Vitamin E treatment significantly decreased apoptosis in ethanol group and restored the increased protein carbonyl and LPO contents and catalase activity to the level of controls. Our findings strongly support oxidative nature of alcohol-induced cellular stress in developing hippocampus and cerebellum, prove that oxidative stress induced cell apoptosis plays a crucial role in pathogenic consequences, and imply that a strong protective effect could be achieved using vitamin E as an antioxidant. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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