Complexity of the response evaluation during primary systemic therapy of breast cancer

Autor:	Magdolna Dank, Gyöngyvér Szentmártoni, Janina Kulka, Zsolt Lengyel, Tamás Györke, László Torgyík, Timea Tokes
Rok vydání:	2014
Předmět:	Cancer Research Pathology medicine.medical_specialty business.industry Urology Tumor response medicine.disease Primary tumor Systemic therapy Breast cancer medicine.anatomical_structure Oncology Medicine business Pathological Lymph node
Zdroj:	Journal of Clinical Oncology. 32:e12010-e12010
ISSN:	1527-7755 0732-183X
DOI:	10.1200/jco.2014.32.15_suppl.e12010
Popis:	e12010 Background: We analyzed the accuracy of different response evaluation score systems in a group of breast cancer patients treated with primary systemic therapy (PST). The score systems tested were based on the metabolical, morphological and proliferation markers of tumor response. Methods: We report on 42 patients in whom staging FDG-PET/CTs were carried out before and after the PST. Maximal SUVs (Standardized Uptake Values) and morphological changes were evaluated in the primary tumor (PT) and axillary lymph node (AL) region. Ki-67 labeling indexes (LI) were measured in the core-biopsies and surgical specimens. Response scoring was performed with the Chevallier and Sataloff (pathological), WHO and RECIST (morphological), EORTC and PERCIST (metabolical) systems and a Ki-67 LI score. Results: The SUVmax and size decreased significantly in the PTs (p
Databáze:	OpenAIRE
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