Sertaconazole-Loaded Cyclodextrin - Polysaccharide Hydrogels as Antifungal Devices§
| Autor: | Juan J. Torres-Labandeira, Angel Concheiro, Carmen Alvarez-Lorenzo, Elena Lopez-Montero, Jose-Fernando Rosa dos Santos |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
chemistry.chemical_classification
Cyclodextrin biology Sertaconazole Hydroxypropyl cellulose technology industry and agriculture Sertaconazole Nitrate biology.organism_classification Polysaccharide Combinatorial chemistry chemistry.chemical_compound Dextran chemistry Self-healing hydrogels Polymer chemistry medicine Candida albicans medicine.drug |
| Zdroj: | The Open Drug Delivery Journal. 3:1-9 |
| ISSN: | 1874-1266 |
| Popis: | The aim of the present work was to develop novel hydrogels for delivering sertaconazole based on cyclodex- trins and various biocompatible polysaccharides. Sertaconazole is an antifungal agent very effective for treatment of Can- dida albicans infections. However its poor aqueous solubility is still a challenging issue for developing suitable formula- tions. Complexation with cyclodextrins is a very attractive route to overcome this limitation, simultaneously enhancing its antifungal effectiveness. Hydroxypropyl--cyclodextrin (HPCD) hydrogels prepared by direct cross-linking in presence of methylcellulose (MC), hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC), carboxymethyl cellu- lose (CMCNa), or dextran were transparent and swelled in water without dissolving, which enables the formation of mi- croenvironments very rich in cyclodextrin cavities responsible for hosting the drug and control its release rate. HP CD hydrogels showed a high capability to load sertaconazole (with partition coefficients from 22 to 470) while still combining high water affinity (superabsorbency), versatile biomechanical properties (hardness and compressibility) and sustained re- lease behavior (up to 4 days). Importantly, sertaconazol-loaded hydrogels showed effectiveness against Candida albicans in culture medium. HPCD-polysaccharide hydrogels could be useful as sertaconazole delivery systems for the treatment of mucosal infections. |
| Databáze: | OpenAIRE |
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