Nonenzymatic Dynamic Kinetic Resolution of in situ Generated Hemithioacetals: Access to 1,3-Disubstituted Phthalans

Autor:	Subhas Chandra Pan, Utpal Nath, Deepan Chowdhury
Rok vydání:	2018
Předmět:	chemistry.chemical_classification In situ 010405 organic chemistry Chemistry Hemithioacetal General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Kinetic resolution chemistry.chemical_compound Intramolecular force Organocatalysis Thiol
Zdroj:	Advanced Synthesis & Catalysis. 360:1628-1633
ISSN:	1615-4150
DOI:	10.1002/adsc.201701518
Popis:	The first nonenzymatic DKR reaction of hemithioacetals is developed. Hemithioacetals were formed in situ via thiol addition and subsequently underwent an intramolecular oxa-Michael reaction. The scope of the reaction was quite broad ranging from aliphatic to aromatic substituents and 1,3-disubstituted-1,3-dihyroisobenzofuran products were obtained in good yields with moderate diastereoselectivities and high enantioselectivities.
Databáze:	OpenAIRE
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