1,3-Dipolar cycloadditions of nitrones to α,β-unsaturated γ-lactams derived from (S)-pyroglutaminol

Autor:	Angèle Chiaroni, N. Dahuron, D. Griffart‐Brunet, Nguyen Van Bac, Nicole Langlois, Abdallah Deyine, Claude Riche, Jean-Marc Delcroix
Rok vydání:	1995
Předmět:	Stereochemistry Chemistry Organic Chemistry Drug Discovery Pyroglutaminol Stereoselectivity Biochemistry Conjugate
Zdroj:	Tetrahedron. 51:3571-3586
ISSN:	0040-4020
DOI:	10.1016/0040-4020(95)00100-m
Popis:	α,β-Unsaturated γ-lactams undergo regio- and stereoselective 1,3-dipolar cycloadditions with N-benzyl and N-methyl nitrones and can act as acceptors in conjugate addition of N-methylhydroxylamine. These reactions give access to highly functionalized pyrrolidones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3cbc37f327538ce106e86fc9a8d7e1d2 https://doi.org/10.1016/0040-4020(95)00100-m Zobrazit plný text záznamu Full Text from ScienceDirect