The effect of dexamethasone on organ-cultured human trabecular meshwork
| Autor: | Atsushi Ishihara, Noboru Fujisawa |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
chemistry.chemical_classification
Pathology medicine.medical_specialty genetic structures biology General Medicine Vacuole Molecular medicine Pathology and Forensic Medicine medicine.anatomical_structure chemistry medicine Extracellular biology.protein Immunohistochemistry sense organs Trabecular meshwork Anatomy Glycoprotein Molecular Biology Elastin Dexamethasone medicine.drug |
| Zdroj: | Medical Electron Microscopy. 27:292-296 |
| ISSN: | 1860-1499 0918-4287 |
| DOI: | 10.1007/bf02349678 |
| Popis: | The effect of dexamethasone (DEX) on the organ-cultured human trabecular meshwork (HTM) was studied with morphometric, autoradiographical, biochemical and immunohistochemical techniques. In approximately 36% of the cases examined, a statistically significant increase in extracellular materials in the endothelial meshwork was found with occurrence of vacuolated trabecular cells. Silver grains showing the presence of the proteins and glycoproteins labeled with3H-methionine were observed in vacuoles of the trabecular cells. In addition, elastin was identified on the surface of the vacuolated trabecular cells. The alterations of the proteins/glycoproteins and elastin in the HTM induced by DEX treatment may play a role in the reduction in aqueous outflow facility. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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