Modification of guanine residues in PNA-synthesis by PyBOP

Autor:	Stephan Pritz, Michael Bienert, Clementine Klemm, Yvonne Wolf
Rok vydání:	2006
Předmět:	Peptide nucleic acid Guanine Organic Chemistry Coupling reagent Biochemistry Combinatorial chemistry humanities Nucleobase chemistry.chemical_compound PyBOP Nucleophile chemistry Drug Discovery HATU Organic chemistry Phosphonium
Zdroj:	Tetrahedron Letters. 47:5893-5896
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2006.06.069
Popis:	The phosphonium-type coupling reagent PyBOP, when applied to the synthesis of peptide nucleic acid (PNA) oligomers, was found to form O 4 -phosphonium compounds of the nucleobase guanine which can be converted into C 4 -modified guanine-derived PNAs by nucleophiles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3ca76bf8a0949f0b2f728478bb498b5a https://doi.org/10.1016/j.tetlet.2006.06.069 Zobrazit plný text záznamu Full Text from ScienceDirect