ChemInform Abstract: Magnesium Bromide Promoted Barbier-Type Intramolecular Cyclization of Halo-Substituted Acetals, Ketals, and Orthoesters

Autor:	Chiar-Dy Chen, Jui-Wen Huang, Man-kit Leung
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Chemistry Reagent Magnesium bromide Intramolecular cyclization General Medicine Lewis acids and bases Medicinal chemistry Catalysis
Zdroj:	ChemInform. 31
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200009081
Popis:	Although acetals, ketals and orthoesters are commonly used as protective groups against organometallic reagents, Grignard reagents derived from halo-acetals, ketals, or orthoesters cyclize intramolecularly under MgBr2 promoted conditions, giving rise to the corresponding cycloalkanol and cycloalkanone derivatives. Our results also suggest a Lewis acid catalyzed push-pull mechanism operating for the cyclization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3ca2262ad1082a6125954a54a11e3672 https://doi.org/10.1002/chin.200009081 Zobrazit plný text záznamu Plný text