Interconvertible of a vitamin B6 coenzyme analog derived from pyridoxal 5′-phosphate and rhodanine

Autor:	Kesel Andreas Johannes, Walter Oberthür, Stephan Urban
Rok vydání:	1996
Předmět:	Stereochemistry Organic Chemistry Biochemistry Nucleobase chemistry.chemical_compound Rhodanine chemistry Drug Discovery Nucleic acid Knoevenagel condensation Coenzyme analog Methylene Vitamin b6 Pyridoxal
Zdroj:	Tetrahedron. 52:14787-14800
ISSN:	0040-4020
DOI:	10.1016/0040-4020(96)00917-9
Popis:	The Knoevenagel condensation product of pyridoxal 5′-phosphate (1) with rhodanine (2) was prepared and identified as (Z)-5-[[3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinyl]methylene]-2-thioxo-4-thiazolidinone (3). The labile (E)-stereoisomer 4 was obtained in a crude form. Its association with the nucleobase adenine was prepared suggesting an affinity to nucleic acids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3c9eb4ad942dae4cebe3cf47bfc2659d https://doi.org/10.1016/0040-4020(96)00917-9 Zobrazit plný text záznamu Full Text from ScienceDirect