Biological properties of 2,4-dioxo-3H-quinoline-3-carboxylic acid and its ethyl ester

Autor:	V. I. Treskach, G. M. Aleksandrova, Yu. F. Krylov, S. V. Gladchenko, P. A. Bezuglyi, A. V. Turov, Igor V. Ukrainets, N. P. Moryakov
Rok vydání:	1992
Předmět:	Pharmacology chemistry.chemical_classification Ethanol Sodium Carboxylic acid Quinoline Acetoacetic ester synthesis chemistry.chemical_element Metal chemistry.chemical_compound Residue (chemistry) chemistry visual_art Drug Discovery visual_art.visual_art_medium Methanol Nuclear chemistry
Zdroj:	Pharmaceutical Chemistry Journal. 26:138-141
ISSN:	1573-9031 0091-150X
Popis:	3-Carbethoxy-4-hydroxy-2-quinolone (II). To the solution of 2.79 g (0.01 mole) of the anilide (I) in i0 ml of absolute methanol is added the solution of 0.26 g (0.02 mole) of metallic sodium in 5 ml of methanol, and the mixture is left for 1 h. Water (50 ml) is added prior to the acidification with HCI to the pH 3-4. The residue is filtered off, washed with water, and dried. The yield was 2.19 g (94%). The mp was 203-204~ (ethanol). C12HIINO 4. The PMR spectrum was as follows: 13.43 (IH, s, OH), 11.53 (IH, s, NH), 7.95 (IH, dd, H-5), 7.63 (IH, td, H-7), 7.31 (IH, d, H-8), 7.22 (IH, td, H-6), 4.37 (2H, q, OCH2), and 1.33 (3H, t, CH3).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3c9eb1f014a84e88922abac007673b9a https://doi.org/10.1007/bf00766452 Zobrazit plný text záznamu Full text from SpringerLink