Exposure to Green Tea Extract Alters the Incidence of Specific Cyclophosphamide-Induced Malformations

Autor:	Jarrett E. Lockard, Betty J. Herring, Hanna Kim, Amanda L. Logsdon, Brittany M. Miller, Ronald D. Hood, Melissa M. Bailey
Rok vydání:	2012
Předmět:	chemistry.chemical_classification Embryology Reactive oxygen species Cyclophosphamide Health Toxicology and Mutagenesis food and beverages Catechin Green tea extract Biology Pharmacology Toxicology chemistry.chemical_compound chemistry Polyphenol medicine Developmental Biology medicine.drug
Zdroj:	Birth Defects Research Part B: Developmental and Reproductive Toxicology. 95:231-237
ISSN:	1542-9733
DOI:	10.1002/bdrb.21011
Popis:	BACKGROUND Green tea extract (GTE) has been shown to have antioxidative properties due to its high content of polyphenols and catechin gallates. Previous studies indicated that catechin gallates scavenge free radicals and attenuate the effects of reactive oxidative species (ROS). Cyclophosphamide (CP) produces ROS, which can have adverse effects on development, causing limb, digit, and cranial abnormalities. The current study was performed to determine if exposure to GTE can decrease teratogenic effects induced by CP in CD-1 mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3c9880d3f8e0f42f1ea57b3e77c7e3d4 https://doi.org/10.1002/bdrb.21011 Zobrazit plný text záznamu Plný text