Role of IL-17 gene polymorphisms in osteoarthritis: A meta-analysis based on observational studies
| Autor: | Nanwei Xu, Yu-Zhou Liu, Yong Huang, Hao-Yu Yang, Xindie Zhou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty business.industry Arthritis Single-nucleotide polymorphism General Medicine Odds ratio Osteoarthritis Cochrane Library medicine.disease 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Meta-analysis Internal medicine Genotype medicine 030211 gastroenterology & hepatology Allele business |
| Zdroj: | World Journal of Clinical Cases. 8:2280-2293 |
| ISSN: | 2307-8960 |
| DOI: | 10.12998/wjcc.v8.i11.2280 |
| Popis: | Background Osteoarthritis (OA) is a chronic complex multifactorial joint disease, and a major degenerative form of arthritis. Existing studies on the association between polymorphisms of the IL-17 gene and the risk of OA in different populations have yielded conflicting findings. Aim To investigate the association between polymorphisms of the IL-17 gene and the risk of OA. Methods We conducted a meta-analysis by systematically searching databases, including PubMed, EMBASE, MEDLINE, Cochrane Library, and Google Scholar to evaluate this association by calculating pooled odds ratios with 95% confidence intervals. Moreover, subgroup analyses stratified by ethnicity and OA type were also conducted. Results In a total of 6 citations involving 8 studies (2131 cases and 2299 controls), 4 single nucleotide polymorphisms were identified. Of these 4 polymorphisms, 2 (rs2275913, rs763780) were common in five case-control studies. Together, the pooled results revealed that the A allele and genotype AA/GA of the rs2275913 polymorphism, and the C allele and genotype CC of the rs763780 polymorphism in the IL-17 gene increased the risk of OA. Furthermore, stratification analyses by ethnicity and OA type showed that the rs2275913 polymorphism increased the risk of OA among Asians and in knee/hip OA, respectively. In addition, stratification analyses also revealed that the rs763780 polymorphism increased OA risk among both Asians and Caucasians in knee/hip OA. Conclusion The rs763780 polymorphism of the IL-17F gene increased the risk of OA, whereas the rs2275913 polymorphism of the IL-17A gene increased the risk of OA only among Asians. Due to the limitations of this study, these findings should be validated in future studies. |
| Databáze: | OpenAIRE |
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