Organoboron Initiated Rh-Catalyzed Asymmetric Cascade Reactions: A Subtle Switch in Regioselectivity Leading to Chiral 3-Benzazepine Derivatives
| Autor: | Aurélie Claraz, Sylvain Darses, Fabien Serpier |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Diene
010405 organic chemistry Stereochemistry Enantioselective synthesis Regioselectivity chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Benzazepine Rhodium chemistry.chemical_compound chemistry Cascade reaction Cascade |
| Zdroj: | ACS Catalysis. 7:3410-3413 |
| ISSN: | 2155-5435 |
| Popis: | An addition-carbocyclization cascade reaction initiated by arylboronic acids and catalyzed by a rhodium/chiral diene complex is described. Starting from N-bridged yne-enoate derivatives, chiral functionalized seven-membered 3-benzazepine heterocycles were obtained with high enantioselectivities, thanks to a rhodium 1,4-shift. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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