Enantioselective synthesis of cyclopropyl δ-lactonealdehydes and dodecyl-5-ene-1-yne-3-ol: advanced intermediates of solandelactone A and B

Autor:	Gajula Ramakrishna, Gullapalli Kumaraswamy, Balasubramanian Sridhar
Rok vydání:	2011
Předmět:	Chemistry Stereochemistry Organic Chemistry Absolute configuration Enantioselective synthesis Transfer hydrogenation Biochemistry Chemical synthesis chemistry.chemical_compound Drug Discovery Bifunctional Chirality (chemistry) Ene reaction Unsaturated fatty acid
Zdroj:	Tetrahedron Letters. 52:1778-1782
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2011.02.008
Popis:	A stereocontrolled synthesis of cyclopropyl δ-lactonealdehydes and dodecyl-5-ene-1-yne-3-ol is accomplished with predictable absolute stereochemistry via organocatalytic and catalytic asymmetric transfer hydrogenation reactions. The salient feature of this protocol is the genesis of chirality through an organocatalytic reaction and utilized for installing a critical bifunctional trans-cyclopropane motif, which is a key segment of every representative member of the oxylipin class of natural products such as solandelactone A and B.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3c8a4407a647934679029e4c48bde8a6 https://doi.org/10.1016/j.tetlet.2011.02.008 Zobrazit plný text záznamu Full Text from ScienceDirect