Lymphoplasmacytic lymphoma and a CD5+ lymphoproliferative process presenting as composite disease in the bone marrow: a report of two cases
| Autor: | Laahn H. Foster, Elizabeth L Courville, Bartosz Grzywacz, Jinbo Fan, Mark Girton |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Histology medicine.diagnostic_test business.industry Chronic lymphocytic leukemia Hematology medicine.disease Pathology and Forensic Medicine Lymphoplasmacytic Lymphoma 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Immunophenotyping hemic and lymphatic diseases 030220 oncology & carcinogenesis Biopsy Medicine Bone marrow CD5 business B-cell lymphoma B cell 030215 immunology |
| Zdroj: | Journal of Hematopathology. 14:61-68 |
| ISSN: | 1865-5785 1868-9256 |
| DOI: | 10.1007/s12308-020-00437-1 |
| Popis: | Correct subclassification of B cell lymphoma requires integration of histologic and immunohistochemical findings in addition to results of flow cytometric immunophenotyping, cytogenetic analysis, and molecular studies. Evaluation for the MYD88 L265P mutation and immunohistochemical staining for LEF1 can be helpful in the workup of small B cell lymphomas. In this case report of two diagnostically difficult cases, we present two patients with lymphoplasmacytic lymphoma (LPL) and a CD5+ lymphoproliferative process presenting as composite disease within the bone marrow. In both cases, integration of ancillary studies and results of biopsy at other sites of disease in addition to a careful histologic review and an expanded immunohistochemistry panel were important for the correct final classification. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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