Über die Häufigkeit von Hämoglobinanomalien und Hämoglobinopathien bei moçambiquanischen Völkerschaften. (Mit Vergleich zwischen Leprösen und Nicht-Leprösen)

Autor:	Helmut Martin, Lütje Behnken, Lothar Nowicki
Rok vydání:	1975
Předmět:	Sickle cell trait medicine.medical_specialty education.field_of_study Hematology business.industry Incidence (epidemiology) Thalassemia Population Physiology Heterozygote advantage General Medicine medicine.disease Internal medicine Medicine Hemoglobin Leprosy business education
Zdroj:	Blut Zeitschrift für die Gesamte Blutforschung. 31:283-290
ISSN:	1432-0584 0006-5242
DOI:	10.1007/bf01634144
Popis:	In 588 bloodsamples of negride natives from Mocambique, preferably Chuabo and Macua, haemoglobin analyses were performed. In 21 cases an increase of Hb A2 was found, indicating the presence of heterozygous beta-thalassaemia, in one case the changes in Hb-analysis were typical for beta-delta-thalassaemia, 18 samples could be shown to contain Hb S, typical for the heterozygous sickle cell trait. Futhermore in 7 cases Hb A2' was found. In two bloodsamples haemoglobin variants were observed, which according to their electrophoretical mobility were assumed to represent Hb D in one case, and Hb G in the other. In the Chuabo population the frequency of the thalassaemia gene was found to be more than twice as high as in the Macua population. In non-lepers Hb S was observed with a remarkable higher incidence than in lepers.
Databáze:	OpenAIRE
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