Safety Pharmacology of Herbal Products
| Autor: | Gert Laekeman |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification biology Traditional medicine Computer science Vernonia amygdalina Safety pharmacology food and beverages 030204 cardiovascular system & hematology Pharmacology biology.organism_classification Sesquiterpene lactone 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry Vernolepin Myristica fragrans Clinical safety Experimental work |
| Zdroj: | Toxicology of Herbal Products ISBN: 9783319438047 |
| DOI: | 10.1007/978-3-319-43806-1_6 |
| Popis: | This chapter aims at a comprehensive review on safety pharmacology. Foxglove and the discovery of acetylsalicylic acid are given as historical examples emerging from benefit-risk balance. Before going to practical examples of in vitro research, a theoretical approach is given to competitive and non-competitive antagonism. Results of experimental work are presented in order to show how early toxic activity can be detected and can even be related to mechanisms of action (e.g., the indole alkaloids of Pterotaberna inconspicua and the sesquiterpene lactone vernolepin from Vernonia amygdalina). If substances can be detected as responsible agents for a biological activity of complex mixtures, the safety approach can be simplified (e.g., eugenol in powder of Myristica fragrans). Pharmacokinetic considerations are important when taking into consideration safety and therapeutic issues of red yeast rice. A pharmacokinetic schedule is given and illustrated with herbal examples. Finally, a framework of questions is proposed to cover quality as well as pre-clinical and clinical safety. |
| Databáze: | OpenAIRE |
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