DIETARY LIPIDS CHANGE THE EXPRESSION OF A PROLIFERATION MARKER IN MURINE 9,10-DIMETHYL-1,2-BENZANTHRACENE-INDUCED SALIVARY TUMORS

Autor:	Adriana B. Actis, Mirta A. Valentich, Silvia Carino, David Cremonezzi, Paul D. Lampe
Rok vydání:	2009
Předmět:	medicine.medical_specialty education.field_of_study Stromal cell Chemistry Mesenchymal stem cell Population General Chemistry Fish oil medicine.disease_cause Endocrinology Biochemistry Apoptosis Internal medicine medicine Proliferation Marker Carcinogenesis education Corn oil Food Science
Zdroj:	Journal of Food Lipids. 16:314-324
ISSN:	1745-4522 1065-7258
DOI:	10.1111/j.1745-4522.2009.01149.x
Popis:	Salivary tumors were induced by 9,10-dimethyl-1,2-benzanthracene injection into the submandibulary gland of mice fed with different dietary lipids. Tumor tissue from 10 mice fed with diets containing corn oil (CO) or fish oil (FO) were immunohistochemically stained for Cx26, β- and γ-catenin, BAX, Bcl-2 and Ki-67. The percentage of animals showing different levels of biomarker expression in epithelial, mesenchymal and stromal cells was calculated in each group. The number of nuclei positive for Ki-67 per 500 total cells was calculated. Reduced expression of Cx26 was observed in FO group as compared to CO. The staining was similar for β-catenin, γ-catenin, BAX and Bcl-2 in both groups. The Ki-67 labeling index was significantly different for CO and FO (0.45–0.40, P
Databáze:	OpenAIRE
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