In vitroandin vivoevaluation of a polylactic acid-bioactive glass composite for bone fixation devices

Autor: Jérôme Chevalier, Pascaline Rivory, Gwenaelle Vergnol, Nathalie Ginsac, Jean-Marc Chenal, Sylvain Meille, Daniel Hartmann, Sandra Balvay
Rok vydání: 2015
Předmět:
Zdroj: Journal of Biomedical Materials Research Part B: Applied Biomaterials. 104:180-191
ISSN: 1552-4973
DOI: 10.1002/jbm.b.33364
Popis: Poly(lactic acid) is nowadays among the most used bioabsorbable materials for medical devices. To promote bone growth on the material surface and increase the degradation rate of the polymer, research is currently focused on organic- inorganic composites by adding a bioactive mineral to the polymer matrix. The purpose of this study was to investigate the ability of a poly(L,DL-lactide)-BioglassV R (P(L,DL)LA-Bioglass V R 45S5) composite to be used as a bone fixation device. In vitro cell viability testing of P(L,DL)LA based composites containing different amounts of Bioglass V R 45S5 particles was investi- gated. According to the degradation rate of the P(L,DL)LA matrix and the cytocompatibility experiments, the composite with 30 wt % of BioglassV R particles seemed to be the best candidate for further investigation. To study its behavior after immersion in simulated physiological conditions, the degradation of the composite was analyzed by measuring its weight loss and mechanical properties and by proceeding with X-ray tomogra- phy. We demonstrated that the presence of the bioactive glass significantly accelerated the in vitro degradation of the poly- mer. A preliminary in vivo investigation on rabbits shows that the addition of 30 wt % of Bioglass V R in the P(L,DL)LA matrix seems to trigger bone osseointegration especially during the first month of implantation. This composite has thus strong potential interest for health applications. V C
Databáze: OpenAIRE
Externí odkaz: