Constituents of the Fruiting Body of Poisonous Mushroom Omphalotus japonicus
| Autor: | Ken-ichi Kimura, Yoshiaki Iizuka, Takako Aboshi, Satoki Aoki, Tetsuya Murayama, Daisuke Arai, Yoshihito Shiono, Toshihiro Murata |
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| Rok vydání: | 2020 |
| Předmět: |
Circular dichroism
Mushroom biology 010405 organic chemistry Chemistry Stereochemistry Omphalotus japonicus Mutant General Chemistry General Medicine 010402 general chemistry biology.organism_classification Sesquiterpene 01 natural sciences Yeast 0104 chemical sciences Illudin chemistry.chemical_compound Drug Discovery Cytotoxicity |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 68:436-442 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | Six new sesquiterpenes, tsukiyols A-C, neoilludin C, and 4-O-methylneoilludins A and B, were isolated from the fruiting body of Omphalotus japonicus (Kawam.) Kirchm. & O. K. Mill. Additionally, six known compounds, illudin S, neoilludins A-B, 5-hydroxydichomitol, ergosterolperoxide, and 3β,5α,9α-trihydroxyergosta-7,22-diene-6-one, were also obtained. Their chemical structures were determined with MS, IR, and NMR spectra and the absolute configurations of neoilludins A-C, 4-O-methylneoilludins A, and B were determined with electronic circular dichroism (ECD). Illudin S and 3β,5α,9α-trihydroxyergosta-7,22-diene-6-one showed cytotoxicity against human acute promyelocytic leukemia HL60 cells. Illudin S, 4-O-methylneoilludin A, B, and tsukiyol C showed growth-restoring activity against mutant yeast via Ca2+-signal transduction. |
| Databáze: | OpenAIRE |
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