Constituents of the Fruiting Body of Poisonous Mushroom Omphalotus japonicus

Autor: Ken-ichi Kimura, Yoshiaki Iizuka, Takako Aboshi, Satoki Aoki, Tetsuya Murayama, Daisuke Arai, Yoshihito Shiono, Toshihiro Murata
Rok vydání: 2020
Předmět:
Zdroj: Chemical and Pharmaceutical Bulletin. 68:436-442
ISSN: 1347-5223
0009-2363
Popis: Six new sesquiterpenes, tsukiyols A-C, neoilludin C, and 4-O-methylneoilludins A and B, were isolated from the fruiting body of Omphalotus japonicus (Kawam.) Kirchm. & O. K. Mill. Additionally, six known compounds, illudin S, neoilludins A-B, 5-hydroxydichomitol, ergosterolperoxide, and 3β,5α,9α-trihydroxyergosta-7,22-diene-6-one, were also obtained. Their chemical structures were determined with MS, IR, and NMR spectra and the absolute configurations of neoilludins A-C, 4-O-methylneoilludins A, and B were determined with electronic circular dichroism (ECD). Illudin S and 3β,5α,9α-trihydroxyergosta-7,22-diene-6-one showed cytotoxicity against human acute promyelocytic leukemia HL60 cells. Illudin S, 4-O-methylneoilludin A, B, and tsukiyol C showed growth-restoring activity against mutant yeast via Ca2+-signal transduction.
Databáze: OpenAIRE