Inhibition of cartilage breakdown by isothiazolones

Autor:	Ronald L. Corbett, Susan R. Sherk, Ronald L. Magolda, Joseph J. Petraitis, Alicia M. Green, Lori L. Bostrom, Matthew M. Abelman, Rachel M. Kindt, Stephen W. Wright
Rok vydání:	1993
Předmět:	Chemistry Cartilage Organic Chemistry Clinical Biochemistry Pharmaceutical Science Arthritis Anatomy Organ culture medicine.disease Biochemistry In vitro medicine.anatomical_structure Drug Discovery medicine Biophysics Molecular Medicine Nasal cartilages Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 3:2875-2878
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(01)80782-4
Popis:	Isothiazolones and isoselenazolones have been found to inhibit IL-1β induced breakdown of bovine nasal cartilage in an organ culture assay. The synthesis and preliminary SAR of these compounds are described. These compounds represent a novel, non-peptide lead series approach to the mediation of the chronic cartilage breakdown associated with arthritic disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3c29d2782a0dc76761e0bb25547579bf https://doi.org/10.1016/s0960-894x(01)80782-4 Zobrazit plný text záznamu