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Background: In several studies, higher plasma levels of histidine-rich glycoprotein (HRG) have been observed in patients with venous thrombosis than in healthy subjects. Apart from environmental factors, such as the use of oral contraceptives, the plasma HRG levels are mainly determined genetically. The most important genetic determinant is P/S186 polymorphisms in exon 5 of the HRG gene which is associated with 40% higher HRG levels. In this study we investigated the relationship between the HRG P/S 186 polymorphism and venous thrombosis. Methods and Results: DNA was available from 466 patients and 471 controls of the Leiden Thrombophilia Study (LETS), a population-based case- control study on venous thrombosis. Both in patients and controls, the genotype distribution of the P/S186 polymorphism was not different from that predicted by the Hardy-Weinberg equilibrium. No association between the genotypes of the P/S186 polymorphism and deep-vein thrombosis was found (PS 186 genotype: OR: 0.97 (CI:0.24,1.70) SS 186 genotype: OR: 1.12 (CI:0.21,2.04), PP 186 is the reference category). Conclusion: The results of this study suggest that the HRG P/S 186 polymorphism is not associated with first venous thrombotic events. |
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