Study of role of inhibitory interneurons in mechanisms of regulation of sensory synapses formed by thalamic and cortical inputs on pyramidal cells of the dorsolateral amygdala nucleus
| Autor: | E. A. Tsvetkov, I. S. Masalov, Nikolai P. Vesselkin |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Post-tetanic potentiation
Physiology Postsynaptic Current musculoskeletal neural and ocular physiology Long-term potentiation Sensory system Inhibitory postsynaptic potential Biochemistry Amygdala chemistry.chemical_compound medicine.anatomical_structure nervous system chemistry Postsynaptic potential medicine Neuroscience Ecology Evolution Behavior and Systematics Picrotoxin |
| Zdroj: | Journal of Evolutionary Biochemistry and Physiology. 45:490-500 |
| ISSN: | 1608-3202 0022-0930 |
| DOI: | 10.1134/s0022093009040070 |
| Popis: | The work deals with study of role of inhibitory interneurons in the process of regulation of sensory currents converging on soma of pyramidal cells of the dorsolateral amygdala nucleus as well as of role of these interneurons in mechanism of regulation of plasticity of amygdala synapses. It has been shown that the part of the spontaneous inhibitory postsynaptic currents recorded on the dorsolateral amygdala pyramidal cells is relatively high and amounts to about a half of the total amount of the recorded events. Analysis of the evoked postsynaptic responses has shown the interneurons to regulate activity and duration of these responses due to the postsynaptic membrane hyperpolarization as a result of activation of GABAA-receptors. Also studied was role of interneurons in providing mechanisms of the long-term potentiation of the synaptic responses evoked by stimulation of cortical and thalamic inputs. Block of effect of interneurons with help of picrotoxin has been shown to lead to an increase of evoked potentiation of synaptic responses. |
| Databáze: | OpenAIRE |
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