ABNORMAL CEREBRAL ENERGY METABOLISM IN NEONATES WITH FOCAL SEIZURES
| Autor: | Bheeshma Rajagopalan, N M Bolas, George K. Radda, James Moorcraft, P L Hope, Philip Sutton |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test business.industry Complex partial seizures Energy metabolism Brain surface Electroencephalography Phosphocreatine chemistry.chemical_compound Inorganic phosphate chemistry Anesthesia Pediatrics Perinatology and Child Health medicine Seizure activity business Adenosine triphosphate |
| Zdroj: | Pediatric Research. 26:519-519 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-198911000-00118 |
| Popis: | Two full-term neonates with focal seizures were studied by spatially-localised phosphorus magnetic resonance spectroscopy (MRS). Both had unilateral cortical lesions on computerised tomography, and have subsequently developed infantile spasms. Electro-encephalography (EEG) showed asymmetrical seizure activity before and after the MRS study. Infant A showed marked asymmetry of global cerebral energy metabolism. The abnormal hemisphere had a phosphocreatine/adenosine triphosphate ratio (PCr/ATP) of 0.87 and PCr/inorganic phosphate (PCr/Pi) ratio of 1.97 compared to 0.41 and 1.40 in the normal hemisphere. Infant B had PCr/ATP of 0.58 and PCr/Pi of 0.92 in the normal hemisphere. The global ratios from the abnormal side were not significantly different, but spatially localised data from tissue 2 cms below the brain surface showed PCr/ATP of 1.05 and PCr/Pi of 2.63. These data suggest that phosphocreatine is increased in the abnormal hemisphere of neonates with established cortical lesions and focal seizures. Similar findings have been reported in adults with complex partial seizures. |
| Databáze: | OpenAIRE |
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