Simulation of drosophila aging in silico

Autor:	V A Chistiakov, Iu V Denisenko
Rok vydání:	2011
Předmět:	Geriatrics gerontology Mechanism (biology) In silico Computational biology Biology biology.organism_classification Prime mover Active oxygen Experimental biology Geriatrics and Gerontology Drosophila melanogaster Gerontology Drosophila Simulation
Zdroj:	Advances in Gerontology. 1:229-234
ISSN:	2079-0589 2079-0570
DOI:	10.1134/s2079057011030040
Popis:	One of the main tasks of modern gerontology is isolation of the group of phenomena essential for aging from epiphenomenona accompanying them. The modern methods of simulation modeling may be the proper tool for correct isolation. The point of their application is reproduction of external aging manifestations in silico, and, in the first place, of standard survival curves with the help of the simplest internal mechanism. Such a mechanism seems to be the prime mover of aging. The aging model of one the most popular objects of experimental biology, a fruit fly Drosophila melanogaster created by us (http://winmobile.biz/moton/moto.html), is based on the assumption that the key mechanism of aging is cellularity loss, the speed of which is determined by the parameters of active oxygen forms generation in motoneurons.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3c09a530f8c0fbe42933aa992708860c https://doi.org/10.1134/s2079057011030040 Zobrazit plný text záznamu Full text from SpringerLink