Quality of CD8 + T cell immunity evoked in lymph nodes is compartmentalized by route of antigen transport and functional in tumor context
| Autor: | Susan N. Thomas, David M. Francis, Margaret P. Manspeaker, Meghan J. O'Melia, Haydn T. Kissick, Nathan A. Rohner |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Multidisciplinary medicine.medical_treatment T cell Biology Acquired immune system 03 medical and health sciences 0302 clinical medicine Lymphatic system medicine.anatomical_structure Cancer immunotherapy Antigen 030220 oncology & carcinogenesis medicine Cancer research Cytotoxic T cell Lymph node CD8 030304 developmental biology |
| Zdroj: | Science Advances. 6 |
| ISSN: | 2375-2548 |
| Popis: | Revealing the mechanisms that underlie the expansion of antitumor CD8+ T cells that are associated with improved clinical outcomes is critical to improving immunotherapeutic management of melanoma. How the lymphatic system, which orchestrates the complex sensing of antigen by lymphocytes to mount an adaptive immune response, facilitates this response in the context of malignancy is incompletely understood. To delineate the effects of lymphatic transport and tumor-induced lymphatic and lymph node (LN) remodeling on the elicitation of CD8+ T cell immunity within LNs, we designed a suite of nanoscale biomaterial tools enabling the quantification of antigen access and presentation within the LN and resulting influence on T cell functions. The expansion of antigen-specific stem-like and cytotoxic CD8+ T cell pools was revealed to be sensitive to the mechanism of lymphatic transport to LNs, demonstrating the potential for nanoengineering strategies targeting LNs to optimize cancer immunotherapy in eliciting antitumor CD8+ T cell immunity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|