ChemInform Abstract: Fragmentations and Rearrangements of 22-Hydroxyl-Substituted Milbemycins - Synthesis of a Key Lactone Intermediate

Autor:	Roderick John Dorgan, Graham S. Macaulay, David O. Morgan, Geoffrey Harold Baker, Nigel Hussain
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Fragmentation (mass spectrometry) Stereochemistry General Medicine Cleavage (embryo) Derivative (chemistry) Lactone
Zdroj:	ChemInform. 25
ISSN:	0931-7597
Popis:	Beckmann fragmentation of 22-oximino milbemycins resulted in the cleavage of the C21–C22 bond to produce a key lactone intermediate which can be used to synthesise new spiroacetals. Cleavage of the C21–O25 bond and recyclisation to produce a furyl derivative is also described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3bea291c4085142bd00e5a29e562ef62 https://doi.org/10.1002/chin.199432242 Zobrazit plný text záznamu Plný text