MAGE-A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer
| Autor: | Shina Liu, Lina Gu, Danjing Yin, Weina Huang, Yunyan Wu, Fei Liu, Meixiang Sang, Baoen Shan |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Oncology endocrine system medicine.medical_specialty business.industry Cancer General Medicine medicine.disease Peripheral blood Metastasis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Antigen 030220 oncology & carcinogenesis Internal medicine Gene expression medicine In patient Lung cancer business neoplasms Gene |
| Zdroj: | Thoracic Cancer. 9:431-438 |
| ISSN: | 1759-7706 |
| DOI: | 10.1111/1759-7714.12571 |
| Popis: | Background MAGE-A genes belong to the cancer/testis antigens family. The prognostic significance of MAGE-A expression in the peripheral blood of patients with lung cancer is unknown. Therefore, this study evaluated the expression and possible prognostic significance of MAGE-A in the peripheral blood of patients with lung cancer. Methods In this study, we detected MAGE-A gene expression in the peripheral blood of 150 patients with lung cancer and 30 healthy donors using multiplex semi-nested PCR and analyzed their correlation with clinicopathological risk factors. Results MAGE-A expression was associated with factors indicating poor prognosis. The expression of MAGE-A and each individual MAGE-A gene were also associated with low overall survival in patients with lung cancer. Conclusion The expression of MAGE-A genes in peripheral blood may act as a poor prognostic marker in patients with lung cancer. |
| Databáze: | OpenAIRE |
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