The Vascular Effects ofIlex pubescens
| Autor: | P. K. T. Pang, M. L. Yang |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Pharmacology
Aqueous extract business.industry Late response Organic Chemistry Histaminergic Pharmaceutical Science Adrenergic Ilex pubescens Tachyphylaxis Analytical Chemistry chemistry.chemical_compound Complementary and alternative medicine chemistry Drug Discovery Molecular Medicine Medicine Cholinergic business Histamine |
| Zdroj: | Planta Medica. 52:262-265 |
| ISSN: | 1439-0221 0032-0943 |
| Popis: | Maodongqing (MDQ) is the common name for the evergreen plant, ILEX PUBESCENS Hook et Arn. In China, an aqueous extract is available for parenteral administration and is used for the treatment of cardiovascular diseases. Among its several pharmacological actions, it is known to be hypotensive. In the present study, its direct vasorelaxing effect was investigated. In rats, MDQ produced two consecutive hypotensive responses. The early response did not involve the adrenergic, cholinergic, histaminergic, prostaglandinergic and bradykininergic systems. The second response was abolished by antihistamines or repeated injection of MDQ (tachyphylaxis). In dogs, only the late response was seen and it was blocked by antihistamines. It seems that when given intravenously, MDQ releases histamine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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