Total synthesis of cyclopiamide A and speradine E
| Autor: | Mina C. Nakhla, John L. Wood, Mauricio Navarro Villalobos, Kendall N. Weeks |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Natural product
010405 organic chemistry Chemistry Decarboxylation Organic Chemistry Aromatization Total synthesis chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Chloride Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Drug Discovery medicine medicine.drug Palladium |
| Zdroj: | Tetrahedron. 74:5085-5088 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2018.02.039 |
| Popis: | Described is a total synthesis of the related alkaloids, cyclopiamide A and speradine E, via a unified strategy that also delivers the natural product aspergilline A. Key steps include metal-free conversion of a malonyl chloride and propargylamine to an intermediate pyrrolinone and a palladium catalyzed decarboxylation/aromatization sequence that delivers the requisite tetracyclic core. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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