Synthesis and properties of esters and amides of pyridine- and 1,2-azolcarbonic acids
| Autor: | Е. А. Dikusar, E. A. Akishina, Vladimir I. Potkin, D. V. Kazak, R. S. Alexeev, Nikolay A. Bumagin |
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| Rok vydání: | 2021 |
| Předmět: |
Isothiazole
010405 organic chemistry Organic Chemistry Condensation 010402 general chemistry Isonicotinic acid 01 natural sciences Medicinal chemistry 0104 chemical sciences Analytical Chemistry Inorganic Chemistry Acylation chemistry.chemical_compound Sodium triacetoxyborohydride chemistry Chemistry (miscellaneous) Pyridine Molecule Isoxazole |
| Zdroj: | Proceedings of the National Academy of Sciences of Belarus, Chemical Series. 57:185-194 |
| ISSN: | 2524-2342 1561-8331 |
| Popis: | Based on esters of nicotinic and isonicotinic acids with hydroxybenzaldehydes, a series of functionally substituted derivatives containing isoxazole and isothiazole heterocycles in the molecule have been synthesized. Azomethines were obtained by condensation of nicotinates and isonicotinates with p-bromoaniline and m-aminophenol, which have been reduced with sodium triacetoxyborohydride to give the corresponding amines. Acylation of amino derivatives of nicotinates and isonicotinates with 5-arylisoxazole- and 4,5-dichloroisothiazolecarbonyl chlorides leads to the esters and amides with isoxazole and isothiazole residues. |
| Databáze: | OpenAIRE |
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