| Autor: |
Sandrine deRibaupierre, Susan Buchanan, Terry M. Peters, Ali R. Khan, Cathie Crukley, Brendan Santyr, Maged Goubran |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Medical Imaging: Image Processing |
| ISSN: |
0277-786X |
| DOI: |
10.1117/12.911058 |
| Popis: |
Surgical resection of epileptic foci is a typical treatment for drug-resistant epilepsy, however, accurate preoperative localization is challenging and often requires invasive sub-dural or intra-cranial electrode placement. The presence of cellular abnormalities in the resected tissue can be used to validate the effectiveness of multispectralMagnetic Resonance Imaging (MRI) in pre-operative foci localization and surgical planning. If successful, these techniques can lead to improved surgical outcomes and less invasive procedures. Towards this goal, a novel pipeline is presented here for post-operative imaging of temporal lobe specimens involving MRI and digital histology, and present and evaluate methods for bringing these images into spatial correspondence. The sparsely-sectioned histology images of resected tissue represents a challenge for 3D reconstruction which we address with a combined 3D and 2D rigid registration algorithm that alternates between slice-based and volume-based registration with the ex-vivo MRI. We also evaluate four methods for non-rigid within-plane registration using both images and fiducials, with the top performing method resulting in a target registration error of 0.87 mm. This work allows for the spatially-local comparison of histology with post-operative MRI and paves the way for eventual registration with pre-operative MRI images. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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