Synthesis of a Panel of Carbon-13-Labelled (Glyco)Sphingolipids

Autor:	Maria J. Ferraz, Gijsbert A. van der Marel, Johan Lugtenburg, Hans van den Elst, Jeroen D. C. Codée, Henrik Gold, Johannes M. F. G. Aerts, Richard J. B. H. N. van den Berg, Mina Mirzaian, Herman S. Overkleeft, Patrick Wisse, Ginger Lutteke
Rok vydání:	2015
Předmět:	Sphingosine Organic Chemistry Carbon-13 Sphingolipid carbohydrates (lipids) Isotopic labeling chemistry.chemical_compound Glycolipid chemistry Biochemistry Lipidomics Moiety lipids (amino acids peptides and proteins) Amine gas treating Physical and Theoretical Chemistry
Zdroj:	European Journal of Organic Chemistry. 2015:2661-2677
ISSN:	1434-193X
DOI:	10.1002/ejoc.201500025
Popis:	The synthesis of a focussed library of sphingolipids differing in the number and position of C-13 labels is described. The synthesised sphingolipids differ in substitution at both the sphingosine amine (either palmitoylated or unmodified) and the sphingosine primary hydroxyl (unmodified or glycosylated). Moreover, C-13 atoms are incorporated into either the sphingosine or the palmitate moiety, or both. This set of compounds is intended for use in relative quantitative lipidomics studies to gain insight into sphingolipid metabolism in healthy and diseased (lysosomal storage disorders) patients and animal models
Databáze:	OpenAIRE
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