Bottom-up Structural Design of Crystalline Drug-Excipient Composite Microparticles via Microfluidic Droplet-based Processing
| Autor: | Ambika Somasundar, Marc Garland, Denise Z. L. Ng, Eunice W. Q. Yeap, Andrew J. Acevedo, Ammu Prhashanna, Fatma Salahioglu, Saif A. Khan, Qisong Xu |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Microfluidics Composite number Excipient Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences law.invention chemistry.chemical_compound Ethyl cellulose law medicine General Materials Science Crystallization chemistry.chemical_classification General Chemistry Polymer 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Solvent chemistry Particle 0210 nano-technology medicine.drug |
| Zdroj: | Crystal Growth & Design. 17:3030-3039 |
| ISSN: | 1528-7505 1528-7483 |
| Popis: | We present a simple, bottom up method for the structural design of solid microparticles containing crystalline drug and excipient using microfluidic droplet-based processing. In a model system comprising 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (ROY) as the drug and ethyl cellulose (EC) as the excipient, we demonstrate a diversity of particle structures, with exquisite control over the structural outcome at the single-particle level. Within microfluidic droplets containing drug and excipient, tuning droplet composition and solvent removal rates allows us to controllably access structural diversity via an interplay of three physical processes (liquid–liquid phase separation, drug crystallization, and polymer vitrification) occurring during solvent removal. Specifically, we demonstrate two levels of structural control—a coarse “macro” particle structure and a finer “micro” structure. Further, we elucidate the key mechanistic elements responsible for the observed structural diversity using a... |
| Databáze: | OpenAIRE |
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