New antifungal prenylated flavanones from Colutea armata

Autor:	Mehdi Hassan Kazmi, Abdul Malik, Zahid Farhad, Sadia Khan, Tanveer Abbas, Itrat Fatima, Shagufta Afaq, Rasool Bakhsh Tareen, Farah Inamullah, Muhammad Ali
Rok vydání:	2019
Předmět:	Antifungal Traditional medicine biology 010405 organic chemistry Chemistry medicine.drug_class General Chemistry biology.organism_classification 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry Prenylation Colutea medicine
Zdroj:	Zeitschrift für Naturforschung B. 74:283-287
ISSN:	1865-7117 0932-0776
DOI:	10.1515/znb-2018-0228
Popis:	Colucons A (1) and B (2), new prenylated flavanones, isolated from the EtOAc-soluble sub-fraction of the whole plant of Colutea armata Hemsl. & Lace along with four known compounds, namely, kenusanone J (3), hesperetin (4), tyrosol (5) and syringaldehyde (6), were reported for the first time from the species armata. Their structures were elucidated by spectroscopic techniques including 1H and 13C NMR (distortionless enhancement by polarization transfer), and 2D NMR experiments. Compounds 1–3 showed significant antifungal activity against Pseudallescheria boydii, Aspergillus niger, Trichophyton mentagrophytes, Macrophomina phaseolina and Candida glabrata, while compound 4 showed moderate antifungal activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3ba60e4eda41f1159e353c195b95b293 https://doi.org/10.1515/znb-2018-0228 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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