The lactase persistence allele –22018 G/A associated with body mass index in an Asian population
| Autor: | Mohsen Aghajanpour-Mir, Ya-Ping Zhang, Hadi Charati, Roghayeh Jabbari Ori, Ali Esmailizadeh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
education.field_of_study medicine.medical_treatment Population Physiology Lactase Biology medicine.disease Obesity 03 medical and health sciences Lactase persistence 030104 developmental biology 0302 clinical medicine Blood pressure Polymorphism (computer science) 030220 oncology & carcinogenesis Genetics medicine Allele education Body mass index |
| Zdroj: | Gene Reports. 19:100621 |
| ISSN: | 2452-0144 |
| DOI: | 10.1016/j.genrep.2020.100621 |
| Popis: | Background A strong association of the –13910 C/T polymorphism with body mass index (BMI) and obesity has been previously reported in Europeans and Chilean goat herders. We aimed to examine the relationship of lactase persistence allele –22018 G/A with BMI and clinical characteristics in an Asian populations. Methods We collected 400 samples from seven Iranian ethnic groups, from whom we investigated their lactose tolerance and screened the genetic variants in their lactase gene locus. Height, weight and clinical characteristics were directly measured. WHO classification of BMI was used. Results The results indicated that Increasing BMI increased significantly the risk of blood pressure and fasting glucose and decreased body temperature in the studied population. We showed that the –22018 G/A allele was positively associated with BMI in Iranian and Asian populations (P Conclusion In conclusion, in Asian population-based 7 major Iranian populations, we found evidence for association of the lactase persistence allele –22018*A with BMI and weight. In the future, meta-analysis of genome-wide association (GWA) studies with larger sample sizes are warranted to confirm our finding. |
| Databáze: | OpenAIRE |
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