Effect of fiber diameter on surface morphology, mechanical property, and cell behavior of electrospun poly(ε-caprolactone) mat
| Autor: | Young Hwan Park, Min Jin Kim, Su Jung Ryu, Hyung Hwan Kim, Chang Seok Ki |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Morphology (linguistics)
Materials science Polymers and Plastics General Chemical Engineering technology industry and agriculture macromolecular substances 02 engineering and technology General Chemistry Adhesion equipment and supplies musculoskeletal system 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Electrospinning 0104 chemical sciences Solvent chemistry.chemical_compound chemistry Ultimate tensile strength Surface roughness Fiber Composite material 0210 nano-technology Caprolactone |
| Zdroj: | Fibers and Polymers. 17:1033-1042 |
| ISSN: | 1875-0052 1229-9197 |
| DOI: | 10.1007/s12221-016-6350-x |
| Popis: | In this study, electrospinning of poly(e-caprolactone) (PCL) and its optimum preparation conditions were examined in detail using various solvent systems, such as formic acid, dichloromethane/dimethyl formamide (DMF), chloroform/DMF, and dichloroethane. The average fiber diameter of the electrospun PCL mat was controlled by the solvent used with a proper concentration of PCL dope solution. Different fiber sizes (0.1, 0.8, 1.9, and 3.4 μm) of uniform PCL mats were fabricated and the effects of fiber size on surface morphology, tensile properties and cell behavior were investigated. Here, we manipulated much broader range of average fiber diameter of the mats, from nano to several micron size of fiber. It was found that the fiber diameter greatly affected topology (surface roughness) and mechanical properties of the electrospun PCL mat and consequently, they influenced the cell behavior (adhesion and proliferation) significantly. We expect that these results will provide more feasible application of electrospun PCL scaffold in tissue engineering through the co-relations in structure and property of PCL fiber mat on cell behavior. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink