Detection of long-lived contaminants in cyclotron-produced radiopharmaceuticals by large area plastic scintillators

Autor: Kenneth A. Van Riper, Keith F. Eckerman, Robert L. Metzger, Richard W. Leggett
Rok vydání: 2018
Předmět:
Zdroj: Journal of Radioanalytical and Nuclear Chemistry. 318:11-15
ISSN: 1588-2780
0236-5731
DOI: 10.1007/s10967-018-5971-5
Popis: In the USA during 2015 over 1,718,500 clinical PET scans were performed in 2380 centers. Patients undergoing these studies will alarm homeland security monitors at borders, ports, and some airports for up to 2 days due to the positron-annihilation photons (0.511 MeV) from the imaging isotope 18F (110 min half-life). In some radiopharmaceuticals, long-lived contaminants generated from the activation and spallation of elements in the HAVAR window of the cyclotron target may also be present in the patient dose. In this work, we have modeled a typical homeland security portal monitor in MCNP, and determined its sensitivity to each of the possible contaminating isotopes found in PET radiopharmaceuticals when distributed in patient phantoms. These data were combined with the time-dependent uptake/retention functions for the contaminating isotopes, to identify the isotopes that can cause alarms for substantial periods of time after the short-lived imaging agent has decayed away.
Databáze: OpenAIRE
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