BOLD MRI in the brain of fetal sheep at 3T during experimental hypoxia
| Autor: | Ulrike Wedegaertner, Gerhard Adam, Manuela Tavares de Sousa, Moritz Birkelbach, Hendrik Kooijman, Jin Yamamura, Roland Fischer, Bjoern P. Schoennagel, Marcela G Weyhmiller |
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| Rok vydání: | 2013 |
| Předmět: |
Control period
medicine.medical_specialty Fetus medicine.diagnostic_test business.industry Cerebrum Magnetic resonance imaging Oxygenation Hypoxia (medical) Confidence interval medicine.anatomical_structure Anesthesia Internal medicine medicine Blood oxygenation Cardiology Radiology Nuclear Medicine and imaging medicine.symptom business |
| Zdroj: | Journal of Magnetic Resonance Imaging. 41:110-116 |
| ISSN: | 1053-1807 |
| DOI: | 10.1002/jmri.24555 |
| Popis: | Purpose To calculate regional fetal brain oxygen saturation (sO2) during hypoxia in sheep. Materials and Methods Eight pregnant ewes were examined at a 3T MR-scanner using blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) to measure signal intensity changes of the fetal brain during a control period and a period of induced hypoxia. Regions of interest were placed in the fetal cerebrum to assess ΔR2* from GRE signal intensity plateaus (Scontrol, Shypoxia) and the relation between ΔR2* and ΔpO2 was analyzed. A probe was placed surgically in the fetal brain to directly measure local pO2 as a reference standard. Baseline and hypoxic pO2 values were recorded and compared (ΔpO2). Results Mean fetal brain pO2 decreased from 14.3 mmHg (95% confidence interval [CI]: 10–19) to 3.4 mmHg (95% CI: 2–5) during hypoxia (mean ΔpO2 = 10.9 mmHg and ΔR2* = −5s−1). A significant correlation between ΔR2* and ΔpO2 was noted (r = 0.93, P |
| Databáze: | OpenAIRE |
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