Changes in Peripheral Blood Level of Regulatory T cells in Patients with Malignant Melanoma During Treatment with Dendritic Cell Vaccination and Low-dose IL-2
| Autor: | P thor Straten, Inge Marie Svane, Jon Bjoern, Marie Klinge Brimnes, Mads Hald Andersen |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Regulatory T cell
business.industry Melanoma medicine.medical_treatment Immunology FOXP3 hemic and immune systems chemical and pharmacologic phenomena General Medicine Dendritic cell medicine.disease Peripheral blood mononuclear cell medicine.anatomical_structure Cancer immunotherapy medicine IL-2 receptor business Progressive disease |
| Zdroj: | Scandinavian Journal of Immunology. 73:222-233 |
| ISSN: | 0300-9475 |
| Popis: | In this study, changes in peripheral blood regulatory T cell (Treg) levels were evaluated in 46 progressive patients with melanoma treated with a dendritic cell-based vaccine and concomitant low-dose IFN-α and IL-2. The regulatory subset of CD4 T cells, characterized by CD25(high) , was prospectively analysed in fresh blood, and treatment-associated quantitative and qualitative changes were analysed. By the 4th vaccine, patients showed a marked increase in CD4+ CD25(high) T cell subset from 6% to 22% (P |
| Databáze: | OpenAIRE |
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