| Autor: |
Tetsuo Shoji, Shuzo Otani, Hirotoshi Morii, Yayoi Ishiguro, Masaaki Inaba, Hideki Tahara, Naoki Takanashi, Hidenori Koyama, Masashi Yanagisawa, Yoshiki Nishizawa |
| Rok vydání: |
2015 |
| Předmět: |
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| DOI: |
10.1159/000420132 |
| Popis: |
Direct effects of human uremic serum on the production of endothelin-1 in cultured porcine endothelial cells were examined in this study. Uremic serum decreased the level of monomeric endothelin-1 secreted into the culture medium by endothelial cells. This effect occurred at a transcriptional step because uremic serum decreased the endothelin-1 mRNA level in those cells. For the partial characterization of this inhibitory activity, uremic serum was fractionated with a centricut column. Uremic serum contains humoral factor(s) larger than 50 kD which suppress the endothelin-1 mRNA level in cultured endothelial cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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