Prophylactic Cranial Irradiation for Patients with Small-Cell Lung Cancer in Complete Remission
| Autor: | Le Péchoux C, P. E.G. Kristjansen, Richard Stephens, Henry N. Wagner, Hiroshi Ueoka, J.P. Pignon, Rodrigo Arriagada, Joseph Aisner, A. Gregor, Anne Auperin, B. E. Johnson |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Induction chemotherapy General Medicine medicine.disease Small-cell carcinoma Gastroenterology Surgery Radiation therapy Internal medicine medicine Cumulative incidence Prophylactic cranial irradiation business Lung cancer Survival analysis Brain metastasis |
| Zdroj: | New England Journal of Medicine. 341:476-484 |
| ISSN: | 1533-4406 0028-4793 |
| Popis: | Background Prophylactic cranial irradiation reduces the incidence of brain metastasis in patients with small-cell lung cancer. Whether this treatment, when given to patients in complete remission, improves survival is not known. We performed a meta-analysis to determine whether prophylactic cranial irradiation prolongs survival. Methods We analyzed individual data on 987 patients with small-cell lung cancer in complete remission who took part in seven trials that compared prophylactic cranial irradiation with no prophylactic cranial irradiation. The main end point was survival. Results The relative risk of death in the treatment group as compared with the control group was 0.84 (95 percent confidence interval, 0.73 to 0.97; P= 0.01), which corresponds to a 5.4 percent increase in the rate of survival at three years (15.3 percent in the control group vs. 20.7 percent in the treatment group). Prophylactic cranial irradiation also increased the rate of disease-free survival (relative risk of recurrence or death, 0.75; 95 percent confidence interval, 0.65 to 0.86; P |
| Databáze: | OpenAIRE |
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