A new α-selective synthetic equivalent for the crotyl anion in additions to imines

Autor:	Manfred Heuschmann, Johannes Betz
Rok vydání:	1995
Předmět:	Crotyl chemistry.chemical_compound chemistry Cerium trichloride Bromide Organic Chemistry Drug Discovery Biochemistry Medicinal chemistry Ion
Zdroj:	Tetrahedron Letters. 36:4043-4046
ISSN:	0040-4039
DOI:	10.1016/0040-4039(95)00670-8
Popis:	Two equivalents of vinylmagnesium bromide add to imines 1 in the presence of cerium trichloride to form homoallylic amines 3 as 2:1-adducts, Z-diastereomers being preferred by a margin of 88:12 to 71:29. Suitable chiral imines 1g-i are transformed to l- products l- 3g-i with high diastereoselectivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3b78f488a6cda99acfc4a367a4454f58 https://doi.org/10.1016/0040-4039(95)00670-8 Zobrazit plný text záznamu Full Text from ScienceDirect