QUANTUM CHEMICAL STUDIES OF NOVEL 4-PHENYLPIPERIDINE OPIATES WITH ANTAGONIST ACTIVITY
Autor: | Stanley Burt, Gilda H. Loew |
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Rok vydání: | 1980 |
Předmět: | |
Popis: | Summary Conformational analysis has been performed on a series of 3R, 4R-4ϕ-piperidine analogues which have antagonist activity that is modulated by substituents at these positions rather than at the amine nitrogen. Analysis of the results obtained by the semi-empirical quantum mechanical method PCILO has led to a consistent hypothesis to explain the structure-activity profiles of these new opiates. |
Databáze: | OpenAIRE |
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