Copper(II) complexes with sulfonamides derived from 2-picolylamine and their use as chemical nucleases
| Autor: | Francisca Sanz, María V. Villa, Marta González-Álvarez, Joaquín Borrás, Mónica Salgado, Benigno Macías |
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| Rok vydání: | 2006 |
| Předmět: |
chemistry.chemical_classification
Sulfonyl Denticity Stereochemistry Coordination complex Sulfonamide law.invention Inorganic Chemistry Crystallography chemistry Unpaired electron law Materials Chemistry Singlet state Physical and Theoretical Chemistry Electron paramagnetic resonance Monoclinic crystal system |
| Zdroj: | Inorganica Chimica Acta. 359:1465-1472 |
| ISSN: | 0020-1693 |
| DOI: | 10.1016/j.ica.2005.11.032 |
| Popis: | Reaction between 2-picolylamine (2-aminomethylpyridine) with 2-mesitylenesulfonyl and 4- tert -butylbenzene sulfonyl chlorides leads to the formation of 2,4,6-trimethyl- N -[pyridin-2-ilmethyl]benzenesulfonamide (Hpmesa) and 4-ter-butyl- N -[pyridin-2-ilmethyl]benzenesulfonamide (Hptbsa). These compounds react with Cu(II) salts to yield coordination compounds with CuL 2 stoichiometry. The immediate environment of the metal ion is a highly distorted tetrahedron, the sulfonamide ligands acting in a bidentate fashion. Compound Hpmesa crystallizes in monoclinic space group P 2 1 /c (number 14), with Z = 4; complex [Cu(pmesa) 2 ] crystallizes in monoclinic space group P 1 ¯ (number 2), with Z = 4 and complex [Cu(ptbsa) 2 ] crystallizes in monoclinic space group Pca 2 1 (number 29), with Z = 4. Both complexes have been characterized by spectroscopic methods. EPR measurements show rhombic spectra with parameters indicating that the unpaired electron is in d x 2 -y 2 d x 2 - y 2 orbital. The two complexes act as chemical nucleases in the presence of ascorbate/H 2 O 2 , the reactive oxygen species being the hydroxyl and the singlet oxygen-like species. |
| Databáze: | OpenAIRE |
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